Crustacean Cardioactive Peptide CCAP |
| Katalog-Nr.GC33690 |
Crustacean Cardioactive Peptide CCAP ist ein hoch konserviertes, amidiertes zyklisches Nonapeptid, das zuerst aus den Perikardorganen der Strandkrabbe Carcinus maenas isoliert wurde, wo es eine Rolle bei der Regulierung des Herzschlags spielt; Crustacean Cardioactive Peptide CCAP moduliert auch die neuronale Aktivität in anderen Arthropoden.
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Cas No.: 309247-84-5
Sample solution is provided at 25 µL, 10mM.
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Crustacean Cardioactive Peptide (CCAP) is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean Cardioactive Peptide (CCAP) also modulates the neuronal activity in other arthropods.
Ultrabithorax and Abdominal-A are not necessary for specification of the CCAP-interneurons, but are absolutely required to prevent the death by apoptosis of the CCAP-efferent neurons[2].
CCAP, FMRFamide and SALDKNFMRFamide increase the mosquito antennal accessory pulsatile organ (APO) and heart contraction rates, increase hemolymph flow velocity in the antennal space[1].
[1]. Suggs JM, et al. CCAP and FMRFamide-like peptides accelerate the contraction rate of the antennal accessory pulsatile organs (auxiliary hearts) of mosquitoes. J Exp Biol. 2016 Aug 1;219(Pt 15):2388-95. [2]. Moris-Sanz M, et al. The study of the Bithorax-complex genes in patterning CCAP neurons reveals a temporal control of neuronal differentiation by Abd-B. Biol Open. 2015 Aug 14;4(9):1132-42.
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