Home>>Crustacean Cardioactive Peptide CCAP
Crustacean Cardioactive Peptide CCAP Catalog No.GC33690

Size Price Stock Qty
1mg
$73.00
In stock
5mg
$295.00
In stock
10mg
$515.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 309247-84-5 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys
Formula C42H58N10O12S2 M.Wt 959.1
Solubility DMSO : 50 mg/mL (52.13 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Crustacean Cardioactive Peptide (CCAP) is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean Cardioactive Peptide (CCAP) also modulates the neuronal activity in other arthropods.

Ultrabithorax and Abdominal-A are not necessary for specification of the CCAP-interneurons, but are absolutely required to prevent the death by apoptosis of the CCAP-efferent neurons[2].

CCAP, FMRFamide and SALDKNFMRFamide increase the mosquito antennal accessory pulsatile organ (APO) and heart contraction rates, increase hemolymph flow velocity in the antennal space[1].

[1]. Suggs JM, et al. CCAP and FMRFamide-like peptides accelerate the contraction rate of the antennal accessory pulsatile organs (auxiliary hearts) of mosquitoes. J Exp Biol. 2016 Aug 1;219(Pt 15):2388-95. [2]. Moris-Sanz M, et al. The study of the Bithorax-complex genes in patterning CCAP neurons reveals a temporal control of neuronal differentiation by Abd-B. Biol Open. 2015 Aug 14;4(9):1132-42.