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GDC-6036

Catalog No.GC64510

Le GDC-6036 (composé 17a) est un puissant inhibiteur de K-Ras G12C avec une IC50 <0,01 μM. Le GDC-6036 a une CE50 de 2 nM dans les cellules K-Ras G12C-alkylation HCC1171.

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GDC-6036 Chemical Structure

Cas No.: 2417987-45-0

Taille Prix Stock Qté
1mg
210,00 $US
En stock
5 mg
525,00 $US
En stock
10mg
896,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

GDC-6036 (compound 17a) is a potent K-Ras G12C inhibitor with an IC50 of <0.01 μM. GDC-6036 has an EC50 of 2 nM in K-Ras G12C-alkylation HCC1171 cells[1].

[1]. Sushant Malhotra, et al. Fused ring compounds. WO2020097537A2.

Chemical Properties

Cas No. 2417987-45-0 SDF Download SDF
Formula C29H32ClF4N7O2 M.Wt 622.06
Solubility Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.6076 mL 8.0378 mL 16.0756 mL
5 mM 0.3215 mL 1.6076 mL 3.2151 mL
10 mM 0.1608 mL 0.8038 mL 1.6076 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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