Islatravir (MK-8591) (Synonyms: 4’Ed2FA, 4′-ethynyl-2-fluoro-2′-Deoxyadenosine, EFDA, MK-8591) |
| Catalog No.GC32306 |
L'islatravir (MK-8591) (MK-8591) est un puissant agent anti-VIH-1, agissant comme un inhibiteur nucléosidique de la transcriptase inverse, avec des CE50 de 0,068 nM, 3,1 nM et 0,15 nM pour le VIH-1 (WT), le VIH- 1 (M184V), VIH-1 (MDR), respectivement.
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Cas No.: 865363-93-5
Sample solution is provided at 25 µL, 10mM.
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Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.
Islatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively[1].
[1]. Ohrui H, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity. Chem Rec. 2006;6(3):133-43.
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