Islatravir (MK-8591) (Synonyms: 4’Ed2FA, 4′-ethynyl-2-fluoro-2′-Deoxyadenosine, EFDA, MK-8591) |
| Catalog No.GC32306 |
이슬라트라비르(MK-8591)(MK-8591)는 뉴클레오시드 역전사효소 억제제로 작용하는 강력한 항HIV-1 제제로, HIV-1(WT), HIV-1에 대해 EC50이 0.068 nM, 3.1 nM 및 0.15 nM입니다. 1(M184V), HIV-1(MDR).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 865363-93-5
Sample solution is provided at 25 µL, 10mM.
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Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.
Islatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively[1].
[1]. Ohrui H, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity. Chem Rec. 2006;6(3):133-43.
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