Islatravir (MK-8591) (Synonyms: 4’Ed2FA, 4′-ethynyl-2-fluoro-2′-Deoxyadenosine, EFDA, MK-8591) |
| Katalog-Nr.GC32306 |
Islatravir (MK-8591) (MK-8591) ist ein starker Anti-HIV-1-Wirkstoff, der als nukleosidischer Reverse-Transkriptase-Hemmer mit EC50-Werten von 0,068 nM, 3,1 nM und 0,15 nM fÜr HIV-1 (WT), HIV- 1 (M184V), HIV-1 (MDR).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 865363-93-5
Sample solution is provided at 25 µL, 10mM.
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Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.
Islatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively[1].
[1]. Ohrui H, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity. Chem Rec. 2006;6(3):133-43.
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