Palmitic Acid Alkyne (Synonyms: Alk-14) |
Catalog No.GC40292 |
L'acide palmitique alcyne (Alk-C16) est un lieur PROTAC À base de chaÎne alkyle qui peut être utilisé dans la synthèse des PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 99208-90-9
Sample solution is provided at 25 µL, 10mM.
Protein S-palmitoylation is the post-translational acylation of proteins and serves to regulate localization, stability, and interaction with associates and substrates.[1] Palmitic acid alkyne is a form of palmitic acid with an ω-terminal alkyne. The terminal alkyne group can be used in linking reactions, known as click chemistry; this chemistry is characterized by high dependability and specificity of the azide-alkyne bioconjugation reactions. [2] [3]The use of palmitic acid alkyne and related lipids in isolating palmitoylated proteins has been described. [4] [5] [6]
Reference:
[1]. Aicart-Ramos, C., Valero, R.A., and Rodriguez-Crespo, I. Protein palmitoylation and subcellular trafficking. Biochimica et Biophysica Acta 1808, 2981-2994 (2011).
[2]. Kolb, H.C., and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discov. Today 8(24), 1128-1137 (2003).
[3]. Lutz, J.F., and Zarafshani, Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry. Adv. Drug Deliv. Rev. 60(9), 958-970 (2008).
[4]. Martin, B.R., and Cravatt, B.F. Large-scale profiling of protein palmitoylation in mammalian cells. Nat. Methods 6(2), 135-138 (2009).
[5]. Yap, M.C., Kostiuk, M.A., Martin, D.D.O., et al. Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry. Journal of Lipid Research 51, 1566-1580 (2010).
[6]. Jiang, H., Khan, S., Wang, Y., et al. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110-113 (2013).
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