Calpains

Calpains (calcium-dependent papain-like enzymes) are a family of intracellular enzymes that consist of complex multi-domains and share a calcium-dependent cysteine protease core. With the development of human genome sequencing, a total of fifteen human calpain genes have been identified (CAPN1 to CAPN15). Calpain 1 (μ-calpain) and calpain 2 (m-calpain) are the two most abundant and well studied members of calpain family in mammals, which are heterodimers characterized by consisting of an isoform-specific large subunit (approximately 80 kDa) and a common small subunit (approximately 28 kDa). The large subunit consists of four domains, domain I (function not clear), domain II (cysteine protease domain), domain III (function not clear) and domain IV (Ca2+-binding domain); while the small subunit consists of two domains, domain V (N-terminal glycine-clustering hydrophobic region) and domain VI (C-terminal Ca2+-binding domain).

Products for Calpains

Cat.No. Nom du produit Informations
GC12152 Acetyl-Calpastatin (184-210) (human)
GC12527 Calpain Inhibitor I, ALLN

AcLeuLeuNleAldehyde, ALLN, MG 101
A non-selective cysteine protease inhibitor
GC16383 Calpain Inhibitor II, ALLM Calpain inhibitor
GC12479 Calpain Inhibitor XII

Z-L-Nva-CONH-CH2-2-Py
L'inhibiteur de calpaÏne XII est un inhibiteur réversible et sélectif de la calpaÏne I (μ-calpaÏne, Ki = 19 nM).
GC10342 Calpeptin
A calpain inhibitor
GC13418 E-64 E-64 est un inhibiteur puissant et irréversible des protéases de cystéine, et sa IC₅₀ est 9nM pour la papaine.
GC11640 MDL 28170

MDL 28170
A cell permeable, selective calpain inhibitor
GC10383 MG-132

ZLeuLeuLeuCHO
MG-132 est un inhibiteur du protéasome puissant, réversible et perméable aux cellules.
GC13450 PD 145305 selective inhibitor of calpains
GC16912 PD 150606 An inhibitor of calpains
GC15066 Z-FA-FMK

ZPheAlaFluoromethyl Ketone
An inhibitor of cysteine proteases, including cathepsin B