15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (Synonyms: 15epi Bimatoprost isopropyl ester, 15(R)Bimatoprost isopropyl ester, 15(R)17phenyl trinor PGF2α isopropyl ester) |
| カタログ番号GC41922 |
15(R)-17-フェニルトリノールプロスタグランジンF2αイソプロピルエステル（15(R)-17-phenyl trinor PGF2α isopropyl ester）は、13,14の両方に二重結合とC-15に反転した（β）水酸基を含むラタノプロスト関連の異性体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 130273-87-9
Sample solution is provided at 25 µL, 10mM.
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15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 µg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.
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