(±)10(11)-EpDPA (Synonyms: (±)10,11-EDP, (±)10,11-EpDPE, (±)10,11-epoxy DPA, (±)10,11-epoxy Docosapentaenoic Acid) |
| カタログ番号GC41212 |
ポリ不飽和脂肪酸のシトクロムP450代謝により、多数の生物活性エポキシレジオイソマーが生成されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 895127-65-8
Sample solution is provided at 25 µL, 10mM.
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Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 µM. (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in inflammatory and neuropathic pain models and to potently inhibit angiogenesis and tumor growth in in vitro assays.
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