Lacidipine (Synonyms: GX 1048, GR 43659X) |
| カタログ番号GC15550 |
ラシジピンは、平滑筋のカルシウム チャネルに作用し、主に末梢動脈を拡張し、末梢抵抗を低下させ、長期にわたる降圧活性を有する、経口活性で選択性の高い L 型カルシウム チャネル遮断薬です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 103890-78-4
Sample solution is provided at 25 µL, 10mM.
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Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Target: Calcium ChannelLacidipine, a novel third-generation dihydropyridine calcium channel blocker, has been demonstrated effective for hypertension. lacidipine protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway [1]. In biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E [2]. lacidipine has some important protective effects on liver of hypertensive irradiated albino rats [3].
References:
[1]. Zhang, A., et al., Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem, 2013. 32(4): p. 1040-9.
[2]. van Amsterdam, F.T., et al., Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med, 1992. 12(3): p. 183-7.
[3]. Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci, 2013. 16(21): p. 1353-7.
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