24-Norursodeoxycholic acid (nor-UDCA) (Synonyms: norUDCA, 24-Norursodeoxycholic Acid, Nourcholic Acid) |
| カタログ番号GC33867 |
24-ノルルソデオキシコール酸 (ノルコール酸) は、UDCA の側鎖が短縮された C23 同族体であり、強力な抗胆汁うっ滞性、抗炎症性、抗線維性を示しています。
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Cas No.: 99697-24-2
Sample solution is provided at 25 µL, 10mM.
24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.
24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and is previously shown to be highly effective in preclinical mouse models of cholestatic and fibrotic liver diseases. 24-norursodeoxycholic acid significantly reduces serum alkaline phosphatase (ALP) levels in a dose-dependent fashion. 24-norursodeoxycholic acid also significantly reduces γ-GT, ALT, and AST serum levels[1].
[1]. Fickert P, et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology. 2006 Feb;130(2):465-81.
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