Allergen Gal d 4 (46-61), chicken (Lysozyme C (46-61) (chicken)) (Synonyms: Lysozyme C (46-61) (chicken)) |
| カタログ番号GC30940 |
アレルゲン Gal d 4 (46-61)、ニワトリ (リゾチーム C (46-61) (ニワトリ)) は、鶏卵白のリゾチームペプチドです。
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Cas No.: 62982-31-4
Sample solution is provided at 25 µL, 10mM.
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Allergen Gal d 4 (46-61), chicken is a hen egg white lysozyme peptide.
Allergen Gal d 4 (46-61), chicken (HEL(46-61)) contains the immunodominant epitope recognized by mice of the k haplotype. The binding is shown to be specific, with a Kd of approximately 2 uM. The direct binding of a hen egg white lysozyme peptide, Allergen Gal d 4 (46-61), is examined to membrane I-Ak (protein encoded in the A locus of the I region) molecules in the presence of detergent. A number of synthetic peptide derivatives, which do not stimulate our T-cell reactive hybridomas, compete for the binding of Allergen Gal d 4 (46-61) to I-Ak and also inhibit the functional presentation of Allergen Gal d 4 (46-61). Inhibitors include a peptide lacking a tyrosine at position 53 and a peptide corresponding to the autologous lysozyme peptide. Presentation is examined with cells or with supported planar phospholipid membranes bearing only I-Ak and Allergen Gal d 4 (46-61)[1].
[1]. Proc Natl Acad Sci U S A. 1986 Jun;83(12):4509-13.
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