Amyloid-β (1-42) Peptide (trifluoroacetate salt) (Synonyms: Aβ (1-42), Aβ42)

Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.^1,2,3 Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.¹ Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.⁴

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