Angiotensin A (trifluoroacetate salt) (Synonyms: Ala-Arg-Val-Tyr-Ile-His-Pro-Phe, DesAsp1-Ala1-Ang II)

Angiotensin A is an angiotensin II type 1 (AT₁) and AT₂ receptor agonist and active metabolite of the peptide hormone angiotensin II .¹ It is formed from angiotensin II via decarboxylation of the N-terminal aspartate residue. Angiotensin A binds to AT₁ and AT₂ receptors in HEK293 cells expressing the rat receptors (IC₅₀s = 0.29 and 0.12 nM, respectively, in radioligand binding assays) and induces calcium mobilization in vascular smooth muscle cells (VSMCs; EC₅₀ = 100 nM). It increases the perfusion pressure in isolated perfused rat kidney (EC₅₀ = 443 nM), an effect that can be reversed by the AT₁ antagonist EXP-3174 . The ratio of angiotensin A to angiotensin II (Ang A/Ang II) in the plasma is increased in patients with end-stage renal failure and serum levels of angiotensin A are decreased in patients with pulmonary arterial hypertension.^1,2

1.Jankowski, V., Vanholder, R., van der Giet, M., et al.Mass-spectrometric identification of a novel angiotensin peptide in human plasmaArterioscler. Thromb. Vasc. Biol.27(2)297-302(2007) 2.Sandoval, J., Del Valle-MondragÓn, L., Masso, F., et al.Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertensionEur. Respir. J.56(1)1902416(2020)