BGG463 (Synonyms: K03859) |
| カタログ番号GC19067 |
BGG463 (K03859) は、経口で活性な II 型 CDK2 阻害剤です 。
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Cas No.: 890129-26-7
Sample solution is provided at 25 µL, 10mM.
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BGG463 (K03859) is an orally active type II CDK2 inhibitor[1].
BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML[2].
References:
[1]. Alexander LT, et al. Type II Inhibitors Targeting CDK2. ACS Chem Biol. 2015 Sep 18;10(9):2116-25.
[2]. Jones K, et al. Cancer Drug Discovery 2010: from molecules to medicine. Expert Rev Clin Pharmacol. 2010 Sep;3(5):613-5.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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