BLU-945 |
| カタログ番号GC63910 |
BLU-945 は、強力で選択性が高く、可逆的で経口的に活性な上皮成長因子受容体 (EGFR) チロシンキナーゼ阻害剤 (TKI) です。 BLU-945 は、L858R および/またはエクソン 19 欠失変異、T790M 変異、および C797S 変異を持つ EGFR を効果的に阻害できます。 BLU-945 は、非小細胞肺がん (NSCLC) を含む肺がんの研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2660250-10-0
Sample solution is provided at 25 µL, 10mM.
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receptor (EGFR). EGFR is a member of the erbB receptor family, which includes transmembrane protein tyrosine kinase receptors. BLU-945 effectively inhibits EGFR with L858R and/or exon 19 deletion mutation, T790M mutation, and C797S mutation. BLU-945 facilitates efficacious dosing and reduces EGFR-mediated on-target toxicities. S BLU-945 has the potential for the research of cancer disease (extracted from patent WO2021133809A1, compound 112)[1].
[1]. John Emmerson Campbell, et al. Inhibitors of mutant forms of egfr. Patent WO2021133809A1.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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