BRD-K98645985 |
| カタログ番号GC39238 |
BRD-K98645985 は、EC50 が ~2.37 μM の BAF (哺乳類 SWI/SNF) 転写抑制阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1357647-78-9
Sample solution is provided at 25 µL, 10mM.
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BRD-K98645985 is a class of 12-membered macrolactam and a BAF (Brg/Brahma-associated factors) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, and without T cell activation or toxicity[1].
[1]. Marian CA, et al. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14.
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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