C2-8 (Synonyms: Polyglutamine Aggregation Inhibitor III) |
| カタログ番号GC43079 |
C2-8は、ポリグルタミン（polyQ）凝集の阻害剤です（再生可能なHDQ51およびPC12細胞に対するIC50はそれぞれ25および0.05μM）。
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Cas No.: 300670-16-0
Sample solution is provided at 25 µL, 10mM.
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C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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