C6 D-threo Ceramide (d18:1/6:0) (Synonyms: N-hexanoyl-D-threo-Sphingosine, D-threo Cer(d18:1/6:0), D-threo Ceramide (d18:1/6:0)) |
| カタログ番号GC40688 |
C6 D-threoセラミドは、生物活性スフィンゴ脂質であり、自然に存在するセラミドの細胞浸透性アナログです。C6 D-threoセラミドは、 vitro内のU937細胞に対して細胞毒性を示し（IC50 = 18μM）、作用します。
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Cas No.: 189894-79-9
Sample solution is provided at 25 µL, 10mM.
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C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater than 5 μM. It enhances IL-4 production induced by phorbol 12-myristate 13-acetate in EL4 T cells when used at a concentration of 10 μM.
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