PRMT5-IN-1 |
| カタログ番号GC36969 |
ヘミアミナールである PRMT5 IN-1 は、強力な選択的タンパク質アルギニンメチルトランスフェラーゼ 5 (PRMT5) 阻害剤であり、PRMT5/MEP50 の IC50 は 11 nM です。 PRMT5 IN-1 はアルデヒドに変換され、生理的条件下で C449 と反応して共有付加物を形成します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2366149-83-7
Sample solution is provided at 25 µL, 10mM.
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PRMT5 IN-1, a hemiaminal, is a covalent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions[1]. IC50: 11 nM (PRMT5)[1]
[1]. https://www.ncbi.nlm.nih.gov/pubmed/31312404
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