Taccalonolide A |
カタログ番号GC37715 |
タッカロノライド A は微小管安定剤であり、タッカ シャントリエリから分離されたステロイドであり、細胞毒性および抗マラリア活性を備えています。タッカロノライド A は、G2-M の蓄積、Bcl-2 のリン酸化、およびアポトーシスの開始を引き起こします。タッカロノライド A は、P 糖タンパク質 (Pgp) および多剤耐性タンパク質 7 (MRP7) を過剰発現する細胞株に対して in vitro で有効であり、SK-OV-3 細胞の IC50 は 622 nM です。
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Cas No.: 108885-68-3
Sample solution is provided at 25 µL, 10mM.
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3]. microtubule[1]
[1]. Tinley TL, et al. Taccalonolides E and A: Plant -derived steroids with microtubule-stabilizing activity. Cancer Res. 2003 Jun 15;63(12):3211-20. [2]. Risinger AL, et al. Taccalonolides: Novel microtubule stabilizers with clinical potential. Cancer Lett. 2010 May 1;291(1):14-9. [3]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8.
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