K-Ras ligand-Linker Conjugate 4 |
カタログ番号GC39226 |
K-Ras リガンド-リンカー コンジュゲート 4 には、K-Ras 動員部分のリガンドと、E3 リガーゼ (VHL、CRBN、MDM2、IAP など) を動員する PROTAC リンカーが組み込まれています。 K-Ras リガンド-リンカー コンジュゲート 4 は、SW1573 細胞で 70% 以上の分解効率を示す強力な PROTAC K-Ras デグレーダーである PROTAC K-Ras Degrader-1 の合成に使用できます。
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Cas No.: 2378261-83-5
Sample solution is provided at 25 µL, 10mM.
K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
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