NSC 636819 |
カタログ番号GC50136 |
NSC 636819 は、KDM4A/KDM4B の競合的かつ選択的な阻害剤です。 KDM4A/KDM4B は、前立腺癌の潜在的な進行因子です。 NSC 636819 は、癌疾患、特に前立腺癌の研究の可能性を秘めています。
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Cas No.: 1618672-71-1
Sample solution is provided at 25 µL, 10mM.
KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID:24971742
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