SI-2 hydrochloride (Synonyms: EPH 116 hydrochloride) |
| カタログ番号GC50307 |
SI-2 (EPH 116 塩酸塩) は非常に有望な SRC-3 阻害剤 (PPI) であり、乳癌細胞死に対する IC50 値は 3 ～ 20 nM です。 SI-2 (EPH 116 塩酸塩) は、毒性と薬物動態プロファイルが大幅に改善されており、許容可能な経口摂取が可能です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1992052-49-9
Sample solution is provided at 25 µL, 10mM.
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Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.
Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID:27084884
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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