Enarodustat (JTZ-951) (Synonyms: JTZ-951) |
| カタログ番号GC33634 |
エナロデュスタット (JTZ-951) は、強力で経口的に活性な低酸素誘導因子プロリルヒドロキシラーゼ阻害剤であり、EC50 は 0.22 μM.
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Cas No.: 1262132-81-9
Sample solution is provided at 25 µL, 10mM.
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Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM; Enarodustat has entered clinical trial for renal anemia.
Enarodustat (JTZ-951) is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition[1].
Enarodustat (1 and 3 mg/kg, p.o.) increases hemoglobin levels in a dose-dependent manner with daily oral dosing in rats[1].
[1]. Ogoshi Y, et al. Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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