BTRX-335140 (Synonyms: CYM-53093) |
| カタログ番号GC39354 |
BTRX-335140 (CYM-53093) は、選択的かつ経口的に活性なκオピオイド受容体 (KOR) 拮抗薬であり、κOR、μOR、δOR に対する拮抗活性があり、IC50 値はそれぞれ 0.8 nM、110 nM、および 6500 nM です。
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Cas No.: 2244614-14-8
Sample solution is provided at 25 µL, 10mM.
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BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively.BTRX-335140 endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. BTRX-335140 can distribute well into the CNS. ADMET (absorption, distribution, metabolism, excretion, and toxicity) [1].
[1]. Guerrero M, et al. Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140). J Med Chem. 2019 Feb 28;62(4):1761-1780.
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