TL 13-112 |
| カタログ番号GC50561 |
TL 13-112 は、強力かつ選択的な ALK-PROTAC 分解剤であり、0.14 nM の IC50 値で ALK 活性を阻害します。 TL 13-112 は、それぞれ 8550 nM、42.4 nM、25.4 nM、および 677 nM の IC50 値で、Aurora A、FER、PTK2、および RPS6KA1 を含む追加のキナーゼの分解も促進します。 TL 13-112 は、セリチニブとポマリドマイドのセレブロン リガンドのコンジュゲートで構成されています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2229037-19-6
Sample solution is provided at 25 µL, 10mM.
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Selective anaplastic lymphoma kinase (ALK) degrader (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h. Negative control TL 13-110 also available.
Powell et al (2019) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID:29660984
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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