IDT307 |
| カタログ番号GC61837 |
有機カチオンMPP+の類似体であるIDT307は、DATに特異的な蛍光基質です(蛍光基質APP+)。
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Cas No.: 1141-41-9
Sample solution is provided at 25 µL, 10mM.
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IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+)[1].
IDT307, an analog of the organic cation MPP+, is transported into CP epithelial cells at the apical (CSF-facing) membrane and sensitive to inhibition by the PMAT inhibitor quinine[1].IDT307 uptake and intracellular accumulation is greatly attenuated by ~70% in CP tissue from the Pmat knockout mouse[1].
References:
[1]. Tao Hu, et al. Molecular mechanisms of organic cation and anion transport at the blood‐CSF barrier. 01 April 2018.
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