CAY10657 |
| カタログ番号GC18782 |
NF-κB/Relファミリーの転写因子は、サイトカイン、ケモカイン、インターフェロン、MHCタンパク質、成長因子、細胞接着分子を含む炎症性遺伝子の発現を誘導し調整します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 494772-86-0
Sample solution is provided at 25 µL, 10mM.
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The NF-κB/Rel family of transcription factors induce and coordinate the expression of pro-inflammatory genes including cytokines, chemokines, interferons, MHC proteins, growth factors, and cell adhesion molecules. Under resting conditions NF-κB dimers are retained in the cytoplasm by a member of the IKB family of inhibitory proteins. Upon activation by cytokines or other stimuli, IKK phosphorylates IKB, initiating a signaling cascade to activate gene transcription. CAY10657 is a thiophenecarboximide derivative proposed to inhibit IKK2. Currently, there are no published reports of its biological activity. However, inhibition of NF-κB activation is likely to be of broad utility in the treatment of inflammatory diseases and cancer.
Review for CAY10657
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
Review for CAY10657
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