JNJ-54175446 |
| カタログ番号GC31098 |
JNJ-54175446 は、強力かつ選択的な脳浸透 P2X7 受容体アンタゴニストであり、hP2X7 受容体と rP2X7 受容体の pIC50 はそれぞれ 8.46 と 8.81 です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1627902-21-9
Sample solution is provided at 25 µL, 10mM.
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JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.
JNJ-54175446 (Compound 14) is a potent and selective brain penetrant P2X7 antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 and rP2X7, respectively. JNJ-54175446 shows less potent activity against mouse, dog and Macaque P2X7 (pIC50, 7.8, 7.9 and 8.1, respectively)[1].
JNJ-54175446 shows dose-dependent occupancy with the ED50 of 0.46 mg/kg, corresponding to plasma EC50 of 105 ng/mL[1].
[1]. Letavic MA, et al. 4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate. Send to
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