AM-1638 |
| カタログ番号GC31607 |
AM-1638 は、EC50 が 0.16 μM の強力な経口投与可能な GPR40/FFA1 アゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1142214-62-7
Sample solution is provided at 25 µL, 10mM.
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AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM.
AM-1638 exhibits moderate cross-species plasma clearance and volume of distribution, resulting in plasma half-lives suitable for evaluation of its antidiabetic properties in mouse, rat, and cynomologus monkey. Moreover, oral administration of full agonist AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%). AM-1638exhibits antidiabetic activity in BDF/DIO mice[1].
[1]. Brown SP, et al. Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. ACS Med Chem Lett. 2012 Aug 15;3(9):726-30.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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