Fumarate hydratase-IN-2 sodium salt |
カタログ番号GC34383 |
フマル酸ヒドラターゼ-IN-2ナトリウム塩(化合物3)は、栄養依存性細胞毒性を有する細胞透過性で競合的なフマル酸ヒドラターゼ阻害剤(Ki=4.5μM)です。
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Sample solution is provided at 25 µL, 10mM.
.Fumarate hydratase is an enzyme of the TCA cycle and cell-permeable inhibitors (1) inhibition of fumarate hydratase can contribute to tumorigenicity in some cells. (2) The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target. Final biochemical studies confirmed dose-dependent, competitive inhibition of this enzyme (3) Chemical inhibition of fumarate hydratase renders cells highly dependent on glucose metabolism for survival.
[1]. Takeuchi T et al. Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity. J Am Chem Soc. 2015 Jan 21;137(2):564-7.
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