8-pCPT-2'-O-Me-Cyclic AMP (sodium salt) |
| カタログ番号GC42630 |
cAMPによって活性化される交換タンパク質（Epac）は、小さなGTPaseであるRap1とRap2のグアニンヌクレオチド交換因子（GEF）です。
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Cas No.: 634207-53-7
Sample solution is provided at 25 µL, 10mM.
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Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-pCPT-2’-O-Me-Cyclic AMP is an 8-(4-chlorophenylthio) analog of cAMP that activates Epacs (AC50 = 1.8 µM). It is a super-activator of Epacs in that it dissociates GDP from Rap1 more strongly than the natural Epac agonist, cAMP. 8-pCPT-2’-O-Me-cAMP is strongly selective for Epac over the cAMP-activated kinase PKA. It does not discriminate between Epac1 and Epac2 and is used extensively to elucidate the roles of these Rap GEFs in cell function.
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