Doxorubicinol (hydrochloride) (Synonyms: 13-Dihydroadriamycin hydrochloride) |
| カタログ番号GC43565 |
ドキソルビシノールは、DNAトポイソメラーゼIIを阻害するアントラサイクリン系抗腫瘍抗生物質であるドキソルビシンの主要な代謝産物であり、二本鎖DNA断裂を誘発します。
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Cas No.: 63950-05-0
Sample solution is provided at 25 µL, 10mM.
Doxorubicinol is the major metabolite of doxorubicin , an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. Doxorubicinol is formed by NADPH-dependent reduction of the side chain carbonyl group of doxorubicin in human, rabbit, and canine cardiac tissue. Doxorubicinol inhibits sodium-potassium-dependent ATPase activity (IC50 = 5.40 μg/ml) and ATP-dependent calcium uptake (IC50= 4.5 μg/ml) in canine cardiac muscle and increases resting stress in contracting rabbit cardiac muscle. Clinically observed cardiotoxicities following doxorubicin treatment have been attributed to the formation and cardiac action of doxorubicinol.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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