Obestatin (human) |
| カタログ番号GC44483 |
オベスタチン (ヒト) は、GPR39 との相互作用を介して食欲と胃腸の運動性を調節する 23 アミノ酸のアミド化ペプチドです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1081110-72-6
Sample solution is provided at 25 µL, 10mM.
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Obestatin is a 23 amino acid peptide hormone with a conserved C-terminal glycine residue and amidation site that is formed by cleavage of the ghrelin and obestatin prepropeptide. It binds to the orphan receptor GPR39 (Kd = 1 nM) and stimulates cAMP production in CHO and HEK293 cells overexpressing human GPR39. Obestatin inhibits contraction of isolated mouse jejunum muscle strips induced by ghrelin . In vivo, obestatin (12.5-1,000 nmol/kg) suppresses food intake in a time- and dose-dependent manner and reduces body weight gain and gastric emptying in mice. Obestatin (0.22 g per animal) also reduces food intake and glucose response without affecting plasma insulin responses in fasted high-fat diet fed mice.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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