ONO-AE3-208 (sodium salt) |
| カタログ番号GC44510 |
ONO-AE3-208は、EP4受容体の拮抗剤であり（Ki = 1.3 nM）、EP3、FP、TP受容体にはより弱い影響を与えます（それぞれKis = 30、790、および2,400 nM）が、他のプロスタノイド受容体には影響を与えません。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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ONO-AE3-208 is an antagonist of the EP4 receptor (Ki = 1.3 nM) that less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors. In wild type mice, it mimics deletion of EP4 by producing severe colitis, with epithelial loss, crypt damage, and inflammation, after treatment with 3% dextran sodium sulfate. ONO-AE3-208 has also been used to implicate EP4 signaling in immune and autoimmune responses, inflammation, and cancer.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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