Cho-Arg (trifluoroacetate salt) |
| カタログ番号GC43250 |
Cho-Argは、L-アルギニンヘッドグループが結合したコレステロール骨格を含むステロイド系カチオン性リピッドです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1609010-56-1
Sample solution is provided at 25 µL, 10mM.
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Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It is cytotoxic to H1299 cells (IC50 = 88.5 μg/ml).
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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