Compound C108 |
| カタログ番号GC43306 |
化合物C108は、乳がんの発生に関与するGTPase活性化タンパク質（SH3ドメイン）結合タンパク質2（G3BP2）の阻害剤です。
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Cas No.: 15533-09-2
Sample solution is provided at 25 µL, 10mM.
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Compound C108 is an inhibitor of the GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2), which is involved in breast tumor initiation. In a mouse xenograft model of breast cancer, compound C108 (1 µM for 24 hours) reduces the proportion of tumor-initiating cells approximately 10-fold compared with untreated cells. In MDA-MB-453 cells, and in the patient-derived xenograft cell line MAXF 401, it diminishes mammosphere formation.
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