Creatine Phosphate (sodium salt hydrate) (Synonyms: Phosphocreatine)

Creatine phosphate is a phosphorylated form of creatine that is involved in energy storage in skeletal muscle and brain.^1,2 It is formed from creatine by creatine kinase. Creatine phosphate (10 mM) reduces hydrogen peroxide- and ferrous ion-induced increases in malondialdehyde (MDA) levels in rat heart microsomes.³ It also prevents hydrogen peroxide-induced decreases in aortic flow, minute work, and peak aortic pressure in isolated perfused rat hearts when used at a concentration of 10 mM. Brain levels of creatine phosphate decrease following mild traumatic brain injury in rats.⁴

1.Wallimann, T., Wyss, M., Brdiczka, D., et al.Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The 'phosphocreatine circuit' for cellular energy homeostasisBiochem. J.281(Pt 1)21-40(1992) 2.Wyss, M., and Kaddurah-Daouk, R.Creatine and creatinine metabolismPhysiol. Rev.80(3)1107-1213(2000) 3.Zucchi, R., Poddighe, R., Limbruno, U., et al.Protection of isolated rat heart from oxidative stress by exogenous creatine phosphateJ. Mol. Cell. Cardiol.21(1)67-73(1989) 4.Signoretti, S., Di Pietro, V., Vagnozzi, R., et al.Transient alterations of creatine, creatine phosphate, N-acetylaspartate and high-energy phosphates after mild traumatic brain injury in the ratMol. Cell. Biochem.333(1-2)269-277(2010)