Creatine Phosphate (sodium salt hydrate) (Synonyms: Phosphocreatine) |
Catalog No.GC52278
One-Click Copy Product Info
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A phosphorylated form of creatine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19333-65-4
Sample solution is provided at 25 µL, 10mM.
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Creatine phosphate is a phosphorylated form of creatine that is involved in energy storage in skeletal muscle and brain.1,2 It is formed from creatine by creatine kinase. Creatine phosphate (10 mM) reduces hydrogen peroxide- and ferrous ion-induced increases in malondialdehyde (MDA) levels in rat heart microsomes.3 It also prevents hydrogen peroxide-induced decreases in aortic flow, minute work, and peak aortic pressure in isolated perfused rat hearts when used at a concentration of 10 mM. Brain levels of creatine phosphate decrease following mild traumatic brain injury in rats.4
1.Wallimann, T., Wyss, M., Brdiczka, D., et al.Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The 'phosphocreatine circuit' for cellular energy homeostasisBiochem. J.281(Pt 1)21-40(1992) 2.Wyss, M., and Kaddurah-Daouk, R.Creatine and creatinine metabolismPhysiol. Rev.80(3)1107-1213(2000) 3.Zucchi, R., Poddighe, R., Limbruno, U., et al.Protection of isolated rat heart from oxidative stress by exogenous creatine phosphateJ. Mol. Cell. Cardiol.21(1)67-73(1989) 4.Signoretti, S., Di Pietro, V., Vagnozzi, R., et al.Transient alterations of creatine, creatine phosphate, N-acetylaspartate and high-energy phosphates after mild traumatic brain injury in the ratMol. Cell. Biochem.333(1-2)269-277(2010)
| Cas No. | 19333-65-4 | SDF | |
| Synonyms | Phosphocreatine | ||
| Canonical SMILES | O=C(CN(C)C(NP([O-])([O-])=O)=N)O.[Na+].[Na+].O | ||
| Formula | C4H10N3O5P • 2Na [XH2O] | M.Wt | 255.1 |
| Solubility | PBS (pH 7.2): 10 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.92 mL | 19.6002 mL | 39.2003 mL |
| 5 mM | 784 μL | 3.92 mL | 7.8401 mL |
| 10 mM | 392 μL | 1.96 mL | 3.92 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)