D9 |
| カタログ番号GC50296 |
D9 は、チオレドキシン還元酵素 (TrxR) の強力かつ選択的な阻害剤であり、EC50 は 2.8 nM です。 D9 は、in vitro と in vivo の両方で腫瘍増殖を阻害する能力を持っています。
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Cas No.: 1527513-89-8
Sample solution is provided at 25 µL, 10mM.
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Potent thioredoxin reductase (TrxR) inhibitor (EC50 = 2.8 nM, IC50 = 0.03 and 0.1 μM in MCF-7 cells and HT-29 cells, respectively). Highly stable in vivo; exhibits no significant ligand exchange with albumin. Inhibits tumor proliferation in vitro and in vivo by inducing cell death. Selectively kills cancer cells.
Zhang et al (2014) Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase. J.Med.Chem. 57 8132 PMID:25249032 |Lin et al (2015) pH-sensitive polymeric nanoparticles with gold(I) compound payloads synergistically induce cancer cell death through modulation of autophagy. Mol.Pharm. 12 2869 PMID:26101892
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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