Dasatinib N-oxide |
| カタログ番号GC45687 |
ダサチニブ N-オキシドは、ダサチニブの微量代謝物です。ダサチニブは、経口で有効な強力な Src/Bcr-Abl 二重阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 910297-52-8
Sample solution is provided at 25 µL, 10mM.
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Dasatinib N-oxide is a major metabolite of the Abl and Src kinase inhibitor dasatinib .1 It is also a potential impurity in commercial preparations of dasatinib.2
|1. Christopher, L.J., Cui, D., Li, W., et al. Biotransformation of [14C]dasatinib: In vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys. Drug Metab. Dispos. 36(7), 1341-1356 (2008).|2. PlachkÁ, K., •vec, F., and NovÁkovÁ, L. Ultra-high performance supercritical fluid chromatography in impurity control: Searching for generic screening approach. Anal. Chim. Acta 1039, 149-161 (2018).
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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