Demeclocycline hydrochloride (Synonyms: Demethylchlortetracycline, Demethyltetracycline) |
カタログ番号GC13212
One-Click Copy Product Info
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デメクロサイクリン塩酸塩はテトラサイクリン系抗生物質です。ライム病、にきび、気管支炎の治療に使用される抗生物質です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 64-73-3
Sample solution is provided at 25 µL, 10mM.
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Demeclocycline hydrochloride is a tetracycline antibiotic; is an antibiotic in the treatment of Lyme disease, acne, and bronchitis.
References:
[1]. Cherrill DA, et al. Demeclocycline treatment in the syndrome of inappropriate antidiuretic hormone secretion. Ann Intern Med. 1975 Nov;83(5):654-6.
[2]. Singer I, et al. Demeclocycline-induced nephrogenic diabetes insipidus. In-vivo and in-vitro studies. Ann Intern Med. 1973 Nov;79(5):679-83.
[3]. Forrest JN Jr, et al. Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone. N Engl J Med. 1978 Jan 26;298(4):173-7.
| Cas No. | 64-73-3 | SDF | |
| 同義語 | Demethylchlortetracycline, Demethyltetracycline | ||
| Chemical Name | (4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carbimidic acid hydrochloride | ||
| Canonical SMILES | CN([C@@]1([H])[C@]2([H])C[C@@]([C@@](O)([H])C3=C(Cl)C=CC(O)=C3C4=O)([H])C4=C(O)[C@]2(O)C(C(C(O)=N)=C1O)=O)C.Cl | ||
| Formula | C21H22Cl2N2O8 | M.Wt | 501.31 |
| 溶解度 | DMF: 1.4 mg/mL,DMSO: 1 mg/mL,PBS (pH 7.2): 3.3 mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.9948 mL | 9.9739 mL | 19.9477 mL |
| 5 mM | 399 μL | 1.9948 mL | 3.9895 mL |
| 10 mM | 199.5 μL | 997.4 μL | 1.9948 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)