(E)-5-(2-Bromovinyl)uracil (Synonyms: BVU) |
| カタログ番号GC41702 |
(E)-5-(2-ブロモビニル)ウラシル（BVU）は、ピリミジン塩基であり、抗ウイルス剤ソリブジンと（E）-5-（2-ブロモビニル）-2'-デオキシウラシル（BVDU）の非活性代謝物であり、体内でBVDUに再生される可能性があります。
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Cas No.: 69304-49-0
Sample solution is provided at 25 µL, 10mM.
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(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time.
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