Endothelin-3 (human, rat) (trifluoroacetate salt) (Synonyms: ET-3) |
| カタログ番号GC43608 |
エンドセリン-3はペプチド収縮血管作用物質であり、内皮細胞受容体ETAおよびETBのリガンドです（それぞれKb = 1.05および1.49）。
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Sample solution is provided at 25 µL, 10mM.
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Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively). It induces β-arrestin recruitment in CHO-K1 cells expressing human ETA and ETB (pD2s = 7.31 and 9.44, respectively). Endothelin-3 increases blood pressure in spontaneously hypertensive and normotensive rats when administered at doses of 310 and 955 pmol/kg, respectively. It also stimulates migration and adhesion of enteric neural crest cells (ENCCs) to the embryonic gut in mice via interaction with ETB. Mutations in the endothelin-3 gene, Edn3, induce distal aganglionosis caused by failed colonization of ENCCs in the hindgut and lack of ENCC migration to the ileo-caecal junction in mice.
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