Foliglurax monohydrochloride (PXT002331 (monohydrochloride)) (Synonyms: PXT002331 (monohydrochloride)) |
| カタログ番号GC31077 |
Foliglurax 一塩酸塩 (PXT002331 (一塩酸塩)) (PXT002331 一塩酸塩) は、選択性が高く強力な脳浸透型代謝型グルタミン酸受容体 4 ポジティブ アロステリック モジュレーター (mGluR4 PAM) であり、EC50 は 79 nM です。
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Cas No.: 2133294-96-7
Sample solution is provided at 25 µL, 10mM.
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Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM), with an EC50 of 79±19 nM[1]. Antiparkinsonian effect[1].
Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].
[1]. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. [2]. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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