FTI-2153 |
| カタログ番号GC60861 |
FTI-2153 は、ファルネシルトランスフェラーゼ (FTase) の強力で選択性の高い阻害剤であり、IC50 は 1.4 nM です。 FTI-2153 は、H-Ras のブロックにおいて、Rap1A プロセッシングよりも >3000 倍強力です (IC50、10 nM)。抗がん作用。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 344900-92-1
Sample solution is provided at 25 µL, 10mM.
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FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC50 of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. Anti-cancer activity[1].
[1]. Sun J, et al. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 1999 Oct 1;59(19):4919-26.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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