(Thr²)-Amyloid β-Protein (1-42) |
カタログ番号GA20309 |
APPのβ-シークレターゼ切断部位に非常に近い変異。アイスランドのAβ42のA2T変異は、ネイティブ配列よりも病原性が低いことが判明しました。前駆体APP A673Tは、アルツハイマー病リスクを減らす最初の人間由来のAPPバリアントでした。A2Tもγ-シークレターゼ切断に影響を与え、細胞ベースの試験では効率的な基質ではありませんでした。
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Sample solution is provided at 25 µL, 10mM.
A mutation very close to the β-secretase cleavage site of APP. The Icelandic mutation A2T of Aβ42 turned out to be less pathogenic than the native sequence. The precursor APP A673T was the first APP variant discovered in humans reducing the r
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