Ganglioside GM2 Asialo Mixture (Synonyms: Asialo-GM2, Asialoganglioside GM2, Gangliotriaosylceramide) |
カタログ番号GC43731 |
ガングリオシドGM2アシアロ(アシアロ-GM2)は、3つの単糖残基と可変鎖長の脂肪酸を含みますが、ガングリオシドM2に存在する唾液酸残基が欠けたグリコスフィンゴ脂質です。
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Cas No.: 35960-33-9
Sample solution is provided at 25 µL, 10mM.
Ganglioside GM2 asialo (asialo- GM2) is a glycosphingolipid containing three monosaccharide residues and a fatty acid of variable chain length but lacking the sialic acid residue present on ganglioside M2. Asialo-GM2 levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively. It also binds to various bacteria, including Pseudomonas isolates derived from cystic fibrosis patients. Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable lengths.
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